Connections between permutation andt-tests: relevance to adaptive methods

Fast permutation tests and related methods, for association between rare variants and binary outcomes.

In large-scale genetic studies, a primary aim is to test for an association between genetic variants and a disease outcome. The variants of interest are often rare and appear with low frequency among subjects. In this situation, statistical tests based on standard asymptotic results do not adequately control the type I error rate, especially if the case : control ratio is unbalanced. In this ar...

Sequential Monte Carlo Methods for Permutation Tests on Truncated Data

The permutation test is one of the oldest techniques for making statistical inferences. Monte Carlo methods and asymptotic formulas have been used to approximate the associated p-values. When data are truncated, however, the permutation null distribution is difficult to handle. We describe here an efficient sequential importance sampling strategy for generating permutations with restricted posi...

specialized methods to teach spelling: comparing three methods

چکیده: بررسی ادبیات مربوطه در کشور در زمینه یادگیری زبان انگلیسی نشان می‎دهد که علی‎رغم اهمیت املا در فرآیند یادگیری به طور عام و یادگیری زبان انگلیسی به طور خاص، این مولفه از جایگاهی متناسب با اهمیت آن برخوردار نیست و عمدتاً نادیده گرفته شده است. تحقیقات گسترده‎ای در خارج از کشور در مورد ماهیت این مولفه صورت گرفته است، در حالی که به جرأت می‎توان گفت در داخل کشور گامی در مورد درک ماهیت آن و فرآی...

Mantel Permutation Tests

Invalid Permutation Tests

Permutation tests are often presented in a rather casual manner, in both introductory and advanced statistics textbooks. The appeal of the cleverness of the procedure seems to replace the need for a rigorous argument that it produces valid hypothesis tests. The consequence of this educational failing has been a widespread belief in a “permutation principle”, which is supposed invariably to give...